Psychiatry Clinic in St. Cloud MN

IV Ketamine & Spravato®

IV Ketamine & Spravato®

Each year, a staggering 13 million adults across the country grapple with the weight of major depression. Among those seeking care, nearly 40% find no respite or full recovery through conventional antidepressant medications.

For those battling the relentless darkness of depression, Ketamine— initially used as an anesthesia medicine in the 1960s, represents a powerful tool in the fight against Major Depressive Disorder and Treatment Resistant Depression (TRD).

IV Ketamine

As delivered by a safe and supervised IV infusion, Ketamine has been demonstrated to promote the growth of new synapses in the prefrontal cortex and dampen the overactive parts of the brain associated with depression to offer a rapid antidepressant effect. The subject of extensive study over the past two decades, IV Ketamine treatment has been clinically proven to provide rapid, robust, and sustained antidepressant effects for many adults who are unresponsive to standard therapies, including SSRIs. Its track record of success has also led to the development of Spravato®, an Esketamine nasal spray.

Spravato®

Esketamine Nasal Spray

Spravato®, approved by the. FDA in 2019 for use in conjunction with an oral antidepressant offers new hope for individuals with Major Depressive Disorder that is treatment-resistant or includes suicidal thoughts. More easily deliverable than IV Ketamine, Spravato® is an intranasal spray that harnesses the power of Esketamine, a potent ketamine derivative. As provided in a comfortable, supervised, and supportive in-office setting Spravato® offers rapid relief from depression symptoms while allowing the oral antidepressant medication to take effect.

How They Compare

Ketamine IV Infusions

Spravato Esketamine Treatments

Chemical Composition
Racemic Ketamine, which is a mixture of R-ketamine & S-Ketamine
Esketamine, which contains only S-Ketamine
Administration
A controlled, in-office IV infusion. Typical appointment length is 90 minutes to two hours
Self-administered intranasal spray While administration is easy and quick, the appointment involves a two-hour comfortable and supervised visit.
Dosage
Based on weight and titrated for effective, controlled, and comfortable delivery.
Available in 56mg and 84mg doses The dosage varies, depending on treatment considerations and individual needs.
Bioavailability
With an IV Ketamine infusion, 100% of the dose is available.
About half the dose of Esketamine is bioavailable when administered as an intranasal spray.
Additional Medications Given
Can be given with or without any other psychiatric medications.
Prescribed in combination with an oral antidepressant
Administration Schedule
Initial course of treatment involves multiple visits over a two-to-three-week period. As indicated and needed, a maintenance schedule will be discussed.
Spravato® starts with two sessions a week initially, gradually reducing to once a week
Insurance Coverage
Considered an off-label use, a Ketamine IV infusion may not be a covered service.
Can be covered in full, with zero out-of-pocket expense. Prior Approval is required
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TMS Treatment for Depression in St. Cloud MN

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Duluth

Existing Patients: (218) 481-0220
New Patients: (218) 464-9455

St. Cloud

Existing Patients: (320) 348-1200
New Patients: (320) 437-8030